Refined & Regenerative

Considered aesthetics focused on expression and skin quality rather than changing the face you recognise.

Skin Polynucleotides

Mastelli Newest polynucleotides and hyaluronic acid aesthetic treatment box

Skin polynucleotides are an injectable regenerative treatment made from highly purified DNA fragments.

They work with your skin's own repair processes to support collagen production, improve hydration and elasticity, and refine texture. The result is skin that looks fresher, firmer and more even, while still looking like you.

They suit skin that looks tired, dull or thinner than it used to, early fine lines, crepey texture and acne scarring. Common areas are the face, neck, décolletage and hands. We use Plinest and Newest depending on needs.

Treatment is a course of 3 sessions 2-3 weeks apart, with results building gradually over months.

Newest® Skin Booster 3 Sessions £649

Newest® Skin Booster 1 Session £249

Treatment length

30 to 45 mins

Results seen

Build over 4 to 8 weeks

Duration of results

6 - 12 months

Downtime required

Minimal

Frequency

3 sessions · 2/3 weeks apart

Under eye Polynucleotides

Close-up of a person with a closed eye, dark eyebrow, and visible facial skin against a dark blue background

The skin under the eyes is the thinnest on the face and often first to show crepiness and fine lines.

Under-eye polynucleotides strengthen and thicken this delicate skin over a course of treatment, softening a hollow, tired look without adding volume.

Because this area is anatomically complex, we assess things carefully first and will tell you honestly if a different approach would suit you better.

Treatment is a course of 3 sessions 2-3 weeks apart, with results building gradually over the following weeks.

Polynucleotide Booster (Plinest®) 3 sessions £549

Polynucleotide Booster (Plinest®) 1 session £199

Treatment length

30 mins

Results seen

Build over 4 to 8 weeks

Downtime required

Minimal

Duration of results

6 - 12 months

Frequency

3 sessions · 2 weeks apart

Polynucleotides FAQs

Invest in the quality of your skin

Book directly if you know what you're looking for, or tell us a little about yourself and we'll help you find the right place to start.